A series of 2-substituted benzylidene-tetralone was prepared from tetralone by using an aldol condensation and then these synthesized benzylidene-tetralone derivatives were further condensed with phenyl hydrazine to give various substituted pyrazoline derivatives. All of these compounds have been characterized by IR, NMR and mass spectral analysis for structure establishment and further evaluated for their antifungal activity against Aspergillus niger (MTCC-282) and Candida albicans (MTCC-227) by agar diffusion method using fluconazole as standard drug. Among benzylidiene derivatives; compounds C1, C2, were least active and compounds C3, C4, C5, were moderately active while among pyrazoline derivatives; compounds C6, C7 were least active and compounds C8, C10, were moderately active and compounds C9 were highly active. When electron-withdrawing substitutions were made on both ring antifungal activity increased in (NO2 > F> Cl) order. The maximum zone of (56%, 69%) was shown by compound C4 among benzylidiene derivative and (76%, 76%) by compound C9 among pyrazoline derivative against Aspergillus niger and Candida albicans respectively.
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